Research progress on obesity, adipokines, and esophageal adeno-carcinoma
10.3969/j.issn.1000-8179.20130285
- VernacularTitle:肥胖脂肪因子与食管腺癌的研究进展
- Author:
Xiaofeng DUAN
;
Peng TANG
;
Zhentao YU
- Publication Type:Journal Article
- Keywords:
esophageal adenocarcinoma;
adipokine;
leptin;
adiponectin
- From:
Chinese Journal of Clinical Oncology
2013;(18):1134-1136
- CountryChina
- Language:Chinese
-
Abstract:
Obesity has rapidly become a pandemic and is associated with increased carcinogenesis, especially esophageal adeno-carcinoma (EA). Adipose tissue is considered an endocrine organ because of its capacity to secrete a variety of adipokines, such as leptin, adiponectin, and resistin. Adipokines have recently been found to be associated with different types of chronic esophageal diseas-es, including gastro-esophageal reflux diseases, Barrett esophagus, and carcinogenesis. First-hand evidence supporting the inhibitory and/or active function of adipokines has been collected on human EA. This review aims to provide important insights into the potential mechanisms of adipokines in EA progression.
