Mast cells and tumor angiogenesis
10.3760/cma.j.issn.1673-422X.2013.07.001
- VernacularTitle:肥大细胞与肿瘤血管生成
- Author:
Li CAO
;
Wei LI
;
Fan DENG
- Publication Type:Journal Article
- Keywords:
Mast cells;
Neoplasms;
Neovascularization,pathologic
- From:
Journal of International Oncology
2013;40(7):483-485
- CountryChina
- Language:Chinese
-
Abstract:
Mast cells (MCs) are bone marrow-derived and tissue-homing immune cells which have important functions.Recruitment and activation in tumors are demonstrated to be mainly mediated by tumorderived stem cell factor (SCF) and its receptor c-kit on MCs.The numbers and distributions of MCs in tumors are closely related to the growth of tumors and angiogenesis.MCs can mediate angiogenesis by releasing a series of angiogenesis factors,so as to promote the progress of tumors.
