Isaacs' Syndrome Associated With Acetylcholine Receptor Antibodies Developed After Removal of Malignant Thymoma.
- Author:
Jin Young SEO
1
;
Byoung Soo SHIN
;
Man Wook SEO
;
Young Hyun KIM
;
Sun Young OH
Author Information
1. Department of Neurology, Chonbuk National University College of Medicine, Jeonju, Korea. ohsun@jbnu.ac.kr
- Publication Type:Case Report
- Keywords:
Isaacs's syndrome;
Acetylcholine receptor antibody
- MeSH:
Acetylcholine;
Antibodies;
Electromyography;
Humans;
Isaacs Syndrome;
Male;
Middle Aged;
Muscles;
Myasthenia Gravis;
Needles;
Peripheral Nerves;
Thymoma
- From:Journal of the Korean Neurological Association
2010;28(3):203-205
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Isaacs' syndrome is a rare and heterogeneous syndrome of continuous muscle fiber activity that originates from peripheral nerves. We report a 56-year-old male patient who showed symptoms of Isaacs' syndrome after the removal of a malignant thymoma. Needle electromyography revealed spontaneously occurring repetitive myokymic discharge in the affected muscles. Acetylcholine receptor (AChR) antibodies were significantly elevated, but clinical and electrophysiologic findings did not indicate the presence of myasthenia gravis. We deduce that in Isaacs' syndrome, raised AChR antibodies may facilitate rather than inhibit cholinergic action.
