Sulfasalazine-induced Reversible Leukoencephalopathy.
- Author:
Sung Yeon SOHN
1
;
Tae Sung LIM
;
Dong Hoon KIM
;
Seong Joon LEE
;
Moon Hee CHOI
;
Hyun Ah KIM
;
So Young MOON
Author Information
1. Department of Neurology, Ajou University School of Medicine, Suwon, Korea. symoon.bv@gmail.com
- Publication Type:Case Report
- Keywords:
Sulfasalazine;
Reversible leukoencephalopathy;
White-matter diseases
- MeSH:
Apathy;
Arthritis, Rheumatoid;
Brain;
Female;
Follow-Up Studies;
Humans;
Leukoencephalopathies;
Middle Aged;
Sulfasalazine
- From:Journal of the Korean Neurological Association
2010;28(3):218-221
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A 50-year-old woman presented with a 4-day history of apathy, perseveration, and confusion. These symptoms appeared 16 days after she had started taking sulfasalazine for rheumatoid arthritis. Brain MRI showed bilateral symmetrical discoid lesions involving the corona radiata. She fully recovered 7 days after stopping the medications. Follow-up brain MRI revealed remarkable improvement of the lesions. The pathomechanisms related to sulfasalazine-induced leukoencephalopathy may be demyelinating processes due to impaired T-cell-mediated immunity.
