Meloxicam versus indomethacin in the prevention of heterotopic ossification after total hip arthroplasty
10.3969/j.issn.2095-4344.2013.39.002
- VernacularTitle:美洛昔康与吲哚美辛防治全髋关节置换后异位骨化的比较
- Author:
Yirong ZENG
;
Linyang JIAN
;
Wenjun FENG
;
Jie LI
;
Feilong LI
;
Sheng HE
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2013;(39):6867-6874
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:In order to avoid heterotopic ossification after total hip arthroplasty, nonsteroidal anti-inflammatory drugs are commonly used for prevention.
OBJECTIVE:To compare the effect of meloxicam and indomethacin in the prevention of heterotopic ossification after total hip arthroplasty.
METHODS:Fifty-one patients who treated in the Department of Orthopedics, the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine from 2010 to 2011 were col ected. Among the 51 patients, nine patients were treated with bilateral total hip arthroplasty, and al the patients had total hip arthroplasty with the posterior-lateral approach. The patients were divided into the control group and the experimental group according to the drugs used after replacement, and the patients in the two groups were administered with indomethacin sustained-release tablet 25 mg+omeprazole capsule 20 mg or meloxicam tablet 15 mg after replacement.
RESULTS AND CONCLUSION:There were no significant differences in the incidence of heterotopic ossification, pain, modified D’Aubigne and Postel scores after replacement between two groups (P>0.05). But, the gastrointestinal adverse reactions of the experimental group were less than those of the control group. The application of meloxicam only can effectively avoid the heterotopic ossification and release pain. Consequently, we recommend meloxicam as postoperative drug for the prevention of heterotopic ossification and pain remission fol owing total hip arthroplasty.
