Intrapertoneal Administration of Dezocine Alleviates Neuropathic Pain in Rats
- VernacularTitle:地佐辛腹腔内注射减轻神经病理性疼痛大鼠的痛行为研究
- Author:
Huiming WANG
;
Weiqing MA
;
Zhangxiang HUANG
;
Yingcai HONG
;
Zhen ZHAO
- Publication Type:Journal Article
- Keywords:
Dezocine;
Morphine;
Rats;
Neuropathic pain
- From:
Journal of Kunming Medical University
2013;(8):44-46
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study wether dezocine (DZ) can attenuate neuropathic pain in rats and to investigate its mechanism.Methods Neuropathic pain was induced by tight ligation of the left L5 spinal nerve of the male SD rats. 24 Spinal nerve ligation (SNL) model rats were randomly divided into three groups:the first group (saline group, n=8), rats were given intraperitoneal injection of 1ml of saline 14 days after SNL surgery; the second group (dezocine group, n=8), rats were given intraperitoneal injection of 5mg/kg of dezocine in 1ml saline 14 days after SNL surgery;the third group (morphine group,n=8),rats were given intraperitoneal injection of 5 mg/kg of morphine 14 days after SNL surgery. Results Intraperitoneal injection dezocine and morphine had significant analgesic effect in neuropathic pain rats. This analgesic effect lasted for 4-6 hours.Continuous injection of morphine for 3 days produced significant tolerance, while continuous injection of dezocine for 7 days still had significant analgesic effect on neuropathic pain. Conclusion Intraperitoneal injection of dezocine and morphine can attenuate SNL neuropathic pain, continuous injection of morphine for 3 days can produce significant tolerance, while continuous injection of dezocine for 7 days still has significant analgesic effect on neuropathic pain.
