The Correlation between Plasma N-terminal Probrain Natriuretic Peptide (NT-proBNP) and the Severity of Coronary Artery Disease
- VernacularTitle:NT-proBNP与冠状动脉病变严重程度的相关性
- Author:
Minan PENG
;
Chuanyin LIU
;
Fengfu WAN
;
Xueqiao WANG
;
Zhiqiang YI
;
Qing HUANG
- Publication Type:Journal Article
- Keywords:
NT-proBNP;
Coronary artery disease;
Severity
- From:
Journal of Kunming Medical University
2013;(8):81-83
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between plasma NT-proBNP and the severity of coronary artery disease. Methods One hundred and eighty five subjects were divided into three groups:83 patients in acute coronary syndromes group, 62 patients in stable angina pectoris group and 40 healthy subjects in normal group. The plasma NT-proBNP concentrations were measured by enzyme-linked immunosorbent assay (ELISA) . The plasma NT-proBNP levels of acute coronary syndrome patients and stable angina patients were analyzed. Furthermore, the coronary syndrome patients were divided into three groups according to the result of angiography:single vessel group, dual-vessel group and multiple-vessel group. The relationship of plasma NT-proBNP levels with the severity of coronary artery disease was analyzed. Results (1) In the group of acute coronary syndromes, the plasma NT-proBNP concentrations were obviously higher than the stable angina pectoris group and normal group (P<0.01) . (2) In the groups of coronary heart disease, the plasma NT-proBNP concentrations of the multiple-vesel group were obviously higher than the single vessel group and the dual-vessel group (P<0.01) . The plasma NT-proBNP concentrations of dual-vessel group were obviously higher than the single vessel group (P<0.01) . (3) The plasma NT-proBNP levels and the severity of coronary lesions were positively correlated (rs=-0.796, P<0.01) . Conclusion The plasma NT-proBNP levels is closely related to the severity of coronary artery disease.
