The basic research of Velvet-feeling in prevention of chemical phlebitis caused by anticancer drugs
10.3760/cma.j.issn.1672-7088.2013.22.029
- VernacularTitle:蓝科肤宁对预防抗肿瘤药物致化学性静脉炎效果的基础研究
- Author:
Yanan XU
;
Xiangyu CHEN
;
Ling YUAN
;
Liping QIAN
- Publication Type:Journal Article
- Keywords:
Chemotherapy;
Phlebitis;
Drug prevention;
Velvet-feeling;
Animal experiment
- From:
Chinese Journal of Practical Nursing
2013;29(22):56-58
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the protective effect of Vdvet-feeling on phlebitis in rabbit ears induced by Fluorouracil.Methods The models of Fluorouracil induced phlebitis in rabbit ears were established.24 rabbits were randomized into three groups:group A used Velvet-feeling for wet dressing,group B was the blank control group C was coated with Hirudoid.The vein was assessed before and after the intervention,and the changes in appearance of vein and the occurrence of phlebitis were observed.The samples of local vein and surrounding tissues were cut off 24 hours after intravenous injection of Fluorouracil and were made pathological sections,HE staining.The pathological damage degree of the vein and surrounding tissues were evaluated by light microscopy.Results The degree of phlebitis in group A and C were lower than group B,there was significant difference.There was significant difference between group A and C at the degree of phlebitis,especially in infiltration of inflammatory cells of vessel wall and perivascular edema.Conclusions Early application of the Velvet-feeling or Hirudoid coating were better in prevention of Fluorouracil induced phlebitis,and wet dressing of Velvet-feeling was better than Hirudoid coating.
