The E-cadherin promoter -160 C/A polymorphism and nasopharyngeal carcinoma in a Chinese population
10.3969/j.issn.1007-3969.2013.07.006
- VernacularTitle:上皮钙黏蛋白启动子-160 C/A位点单核苷酸多态性与鼻咽癌的相关性
- Author:
Na JIN
;
Kai HU
;
Qingyao ZHU
;
Chao YUAN
;
Tao WANG
- Publication Type:Journal Article
- Keywords:
E-cadherin;
Single nucleotide polymorphism;
Nasopharyngeal carcinoma
- From:
China Oncology
2013;(7):512-518
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose:The E-cadherin as a pivotal structural protein is important for cellular polarity and maintainance of normal tissue morphology and cellular differentiation. Recently some study investigated the impact of the C/A genetic polymorphism at-160 from the site of the E-cadherin gene promoter on susceptibility in NPC. To evaluate the association of the E-cadherin gene promoter-160 C/A single nucleotide polymorphism (SNP) and nasopharyngeal carcinoma risk in a Chinese population, we designed a hospital-based case-control study. Methods:Subjects included in this study were 303 patients deifnitely diagnosed with NPC, and 318 matched healthy controls. We used TaqMan Probe method for analyzing polymorphism. Results:The A/A genotype was associated with increased risk of NPC after being adjusted for age and gender (adjusted OR=2.09, 95%CI:1.03-4.22, P=0.04). When 2 gender groups were analysed respectively, female group with A/A genotypes showed a higher risk (OR=7.57, 95%CI:1.57-36.47, P=0.012). Besides, among NPC patients compared with males A/A genotype, females with A/A genotype had a signiifcant risk(OR=2.66, 95%CI:1.14-6.20, P=0.024). Conclusion:The A/A genotype of E-cadherin promoter-160 C/A might be genetic risk factor for NPC, especially female patients.
