Preparation and Research on the Aniti-Tumor Activity of Adriamycin Self-assembled Nanoparticles
- VernacularTitle:阿霉素自组装纳米粒的制备及其抗肿瘤活性的研究
- Author:
Jiazhen ZHU
;
Fanzhu LI
- Publication Type:Journal Article
- Keywords:
adriamycin;
cholesterol-modified pul ulan;
self-assembled nanoparticles;
in vitro release;
antitumor
- From:
Journal of Zhejiang Chinese Medical University
2013;(8):951-955
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To prepare adriamycin self-assembled nanoparticles, and study the in vivo anti-tumor activity. [Methods]The self-assembled adri-amycin loaded cholesterol-modified pul ulan nanoparticles were prepared by dialysis and were characterized by morphology for particle size,Zeta potential, entrapment efficiency,drug loading content.They were incubated with U251 cel s to assess the inhibition ability of the self-assembled adriamycin-loaded cholesterol-modified pul ulan nanoparticles. [Results]The morphology of self-assembled adriamycin loaded cholesterol-modified pul ulan nanoparticles was spherical. The mean particle size, Zeta potential, entrapment efficiency and drug loading were (112.8 ±1.02)nm,(-27.2±0.246)mV,(67.14±1.21)% and (7.65±0.58)%, respectively.The profiles of release were expressed wel by Higuchi equation. When the dosages were 25μg·mL-1 plus, the inhibiton ability against U251 was stronger than adriamycin solution( P<0.01).[Conclusion]The self-assembled adriamycin loaded cholesterol-modified pul ulan nanoparticles exhibited more cycitoxic activity against U251 than adriamycin solution.
