Study on Acute Toxicity and Anti-inflammatory Effects of Coffee Residue Extract

VernacularTitle:咖啡渣提取物的急性毒性与抗炎作用研究
Author: Yinfeng TAN ; Hongfu LI ; Xiaoyang WANG ; Junqing ZHANG ; Xiaoping LIAO
Publication Type:Journal Article
Keywords: Coffee residue; acute toxicity; anti-inflammation
From: World Science and Technology-Modernization of Traditional Chinese Medicine 2013;(4):664-666
CountryChina
Language:Chinese
Abstract: This study was aimed to preliminarily evaluate the acute toxicity and anti-inflammatory effects of coffee residue extract. The test maximum tolerated dose was applied in mice by gavage to observe the acute toxicity of coffee residue extract. Mice acute inflammation model was induced by xylene and glacial acetic acid. The gavage administration of coffee residue extract (1.00, 2.00, 3.00 g?kg-1, in terms of crude drug) was given 7 days con-tinuously. The ear swelling rate and celiac capillary permeability were measured. The results showed that the ex-tract of coffee residue maximum tolerated dose in mice is 8 . 60 g?kg -1 ( in terms of crude drug ) . The coffee residue extract of 3 . 00 g?kg-1 is able to inhibit ear swelling induced by xylene in mice ( P < 0 . 05 ) and the ex-cessive celiac capillary permeability ( P < 0 . 05 ) . It was concluded that the coffee residue extract have certain an-ti-inflammation activities.