Study on Key Theoretical and Technological Issue of Combination Compatibility and Single Determinacy for Administration of Chinese Materia Medica Preparations
10.11842/wst.2013.04.034
- VernacularTitle:中药制剂单用确定性与合用调配性的关键理论技术问题研究
- Author:
Fuyuan HE
;
Kaiwen DENG
;
Wenlong LIU
;
Yantao YANG
;
Jilian SHI
- Publication Type:Journal Article
- Keywords:
Pharmaceutics of CMM;
determinacy;
compatibility;
co-network compatibility and rainbow potential;
supramolecule;
immunity chip;
network chromatopharmacodynamics
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2013;(4):790-798
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to analyze characteristics of Chinese Materia Medica ( CMM ) preparations in order to identify the long-term development direction of this discipline and suggest key questions and strategies to solve the problems. According to the development track of CMM preparation, traditional Chinese medicine (TCM) basic theories and modern new drug research techniques were combined with the author's experiences on modernization study of TCM. This article discussed key issues of CMM preparation development direction, characteristics and is-sues need to be solved and their countermeasures. The results showed that the development direction for CMM preparation discipline should entirety unify CMM preparation system. The medical resource should be convenient which include animal, plant and mineral products. The single determinacy (effectiveness, stability and controlled) and compatibility (prediction, optimization and lowest toxin) will be applied in the guidance of CMM preparation system. In order to achieve goals mentioned above, key issues need to be solved are efficiency categories for in-gredients, genetical stabilities and one sampling charge, emigration rules of properties among ingredients, the ki-netic and stable rules of ingredient extraction, controlled rules for integral models or for disorder and torrent, e-valuation rules in vivo and in vitro, microscopic and macroscopic qualities, determinacy for single administration and compatibility for combination applications. It was concluded that the CMM preparation is a series of integral unified effective ingredient preparations that behave the determinacy for single administration and compatibility for combination applications.
