Electro-acupuncture treatment impact as well as the mechanisms of learning and memory abilities of AD rats
10.3969/j.issn.1671-8348.2013.21.002
- VernacularTitle:电针治疗对AD大鼠学习记忆能力及细胞周期蛋白P53、P21表达的影响
- Author:
Qi SU
;
Deen XU
- Publication Type:Journal Article
- Keywords:
EA;
Alzheimer′s disease;
learning and memory
- From:
Chongqing Medicine
2013;(21):2444-2448
- CountryChina
- Language:Chinese
-
Abstract:
Objective of electroacupuncture(EA) of Alzheimer′s disease(AD) rat learning and memory ability and plasma SOD , MDA content in brain P53 ,P21 expression .Methods The normal 36 SD rats ,were randomly divided into sham operation group , model group and EA group .EA group acupuncture “Baihui” ,“Taixi” ,“Zusanli” treatment ,through the Morris water maze test in rats behavioral changes ,spectrophotometric observation of SOD and MDA in rat plasma levels ;observation of rat brain P53 ,P21 ex-pression by immunofluorescence .Results Compared With the model group ,group EA escape latency ,longer in the third quadrant of the activities of the time ,the number of crossing platform position increased ,decreased the elevated plasma SOD level ,MDA lev-el ,reduce the expression of brain P53 ,P21 ,and the difference was statistically significant (P<0 .01) .Conclusion electro-acupunc-ture treatment can improve the Aβ1-42-induced AD rat spatial learning and memory ability ,may be lowered P53 ,P21 protein ex-pression increase SOD activity and MDA .