Effect of aspirin resistance on cardiovascular events in non-insulin-dependent diabetes mellitus patients
10.3969/j.issn.1671-8348.2013.21.017
- VernacularTitle:阿司匹林抵抗在2型糖尿病患者心血管事件中的影响研究
- Author:
Gang WU
;
Lu CHENG
- Publication Type:Journal Article
- Keywords:
diabetic mellitus;
aspirin resistance;
adverse cardiovascular events
- From:
Chongqing Medicine
2013;(21):2486-2488
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of aspirin resistance on cardiovascular events in non-insulin-dependent diabetes melli-tus patients .Methods 496 patients with non-insulin-dependent diabetes mellitus received daily aspirin therapy (100mg/d) 4 weeks were recruited from Jun .2006 to Sept .2010 .Platelet aggregation was measured by light transmission aggregometry .The patients were divided into three groups :aspirin resistance group ,aspirin semi-resistance group and aspirin-sensitive group .The clinical bio-chemistry indications and the adverse cardiovascular events were collected .Results 11 .69% of patients were found to be resistant to aspirin therapy ,and 37 .90% of patients to be aspirin semi-responders .There were 67 .48% female in aspirin resistance group and aspirin semi-responders .The preprandial glucose of group AR and ASR was higher than that of group AS (P<0 .05) .The HbA1C and TG of group AR were higher than those of group AS(P<0 .05) .There was statistically significant difference of the rate of car-diovascular events .Conclusion The measure of platelet aggregation should be taken in the diabetic mellitus patients and pay atten-tion on the dose of aspirin recommended .Particular attention is should also devote to the incidence of adverse cardiovascular events .
