Kikuchi-Fujimoto's disease with meningitis and abnormal serum immune phenomena: a case report and review
10.3760/cma.j.issn.1006-7876.2013.09.004
- VernacularTitle:伴发脑膜炎且血清免疫异常的坏死性淋巴结炎一例临床特点及文献回顾
- Author:
Yaqing SHU
;
Wei QIU
;
Xueping ZHENG
;
Zhengqi LU
;
Jianning CHEN
;
Xueqiang HU
- Publication Type:Journal Article
- Keywords:
Histiocytic necrotizing lymphadenitis;
Meningitis;
Antibodies,antinuclear;
Ribonucleoproteins;
Immunoglobulin G
- From:
Chinese Journal of Neurology
2013;46(9):592-596
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical characteristics in patients with histiocytic necrotizing lymphadenitis (also called Kikuchi-Fujimoto' s disease,KD) and meningitis.Methods We reported a patient who developed meningitis preceding the other presentations of KD with abnormal serum autoimmune phenomena,and systematically reviewed 19 cases of KD with meningitis that had been reported worldwide,and analyzed the clinical parameters and treatments.Results The present case was a 25-year-old female subject with serum antinuclear factor antibody and anti-ribonucleoprotein antibody positive.The patient recovered after treatment with steroid and no recurrence was appeared.Among the 19 patients,the average age was 20.2 years,sex ratio was 10:9 (10 female:9 male),7 patients had abnormal serum autoimmune phenomena,7 patients'initial symptom was meningitis and 5 patients were administrated with steroid.Conclusions The onset age in KD with meningitis is earlier than the common KD,and sex ratio in KD with meningitis is close to 1∶ 1.A definitive diagnosis of the disease is determined by a lymph node biopsy at present.
