Correlations among the expressions of PPARγ, ERα, and ERβin endometrial carcinoma
10.3969/j.issn.1000-8179.20130449
- VernacularTitle:PPARγ ERα和ERβ在子宫内膜癌的表达及其相关性分析*
- Author:
Xinxin HOU
;
Meng ZHAO
;
Hongxia WANG
;
Guiyu ZHANG
- Publication Type:Journal Article
- Keywords:
endometrial neoplasm;
peroxisome proliferator-activated receptor gamma;
estrogen receptor alpha;
estrogen receptor beta
- From:
Chinese Journal of Clinical Oncology
2013;(17):1029-1033
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expressions of peroxisome proliferator-activated receptor gamma (PPARγ), estrogen re-ceptor alpha (ERα), and estrogen receptor beta (ERβ) in endometrial carcinoma and to analyze their correlations and clinical signifi-cance. Methods:Immunohistochemical assay and Western blot were used to detect the expressions of PPARγ, ERα, and ERβin normal endometrial tissues and well-differentiated, moderately differentiated, and poorly differentiated endometrial carcinomas. Results:PPARγexpression was significantly lower in endometrial carcinoma than in the normal endometrium and was intimately associated with cli-ni-copathologic variables. ERαexpression gradually decreased in moderately and poorly differenti-ated endometrial carcinomas. How-ever, no significant differences were found between the normal endometrium and well-differentiated endometrial carcinoma. ERβex-pression only decreased in the poorly differentiated endometrial carcinoma. No significant association was observed between ERβand clinicopathologic variables. Pearson correlation analysis showed a significant positive cor-relation between the expressions of PPARγand ERα. No correlations were observed between the expressions of ERαand ERβand between that of ERβand PPARγ. Conclusion:The expression lev-els of PPARγand ERαwere significantly associated with the clinicopathologic stage of endometrial carcinoma, and have essential functions in endometrial tumorigenesis and tumor progression.
