Epithelial-mesenchymal transition and drug resistance of tumors
10.3969/j.issn.1000-8179.20121180
- VernacularTitle:上皮-间质转化与肿瘤耐药性的研究进展*
- Author:
Ling YUAN
;
Zhaoxia WANG
- Publication Type:Journal Article
- Keywords:
epithelial-mesenchymal transition;
tumor;
drug resistance
- From:
Chinese Journal of Clinical Oncology
2013;(17):1068-1071
- CountryChina
- Language:Chinese
-
Abstract:
Differentiated epithelial cells could be transformed into mesenchymal cells through the epithelial-mesenchymal transi-tion (EMT), which is important for tumorigenesis and metastasis. Recent studies suggest that EMT is closely correlated to the resistance to chemotherapy of tumors. This chemoresistance could enhance tumor malignancy, which includes the induction of the EMT pheno-type. The paper reviews the research progress on EMT and its association with drug resistance of tumors.
