Role of HIF-1αin hypoxic microenvironment of tumor and the targeted therapy
10.3969/j.issn.1000-8179.20130565
- VernacularTitle:HIF-1α在肿瘤乏氧微环境中的作用及其靶向治疗的研究进展*
- Author:
Jian WANG
;
Jihui HAO
- Publication Type:Journal Article
- Keywords:
HIF-1α;
tumor;
hypoxia;
mechanism;
therapy
- From:
Chinese Journal of Clinical Oncology
2013;(17):1072-1075
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia is a common characteristic in solid tumors. With the regulation of the transcription of multiple target genes, HIF-1αplays an important role in the energy metabolism, proliferation, and apoptosis of tumor cells. HIF-1αcontributes to the adapta-tion of tumor cells and tissue to hypoxia stress through these processes. It also promotes tumor angiogenesis and increases their inva-sive ability and the resistance to radio and chemotherapy. Cancer treatment targeting on HIF-1αis an important potential therapy.
