Effect of Wen-Yang Jie-Du Hua-Yu Granules on TLR4 and NF-кB Expression of Rat Hepatic Failure Model with Intestinal Endotoxemia
10.11842/wst.2013.05.004
- VernacularTitle:温阳解毒化瘀颗粒对肝衰竭肠源性内毒素血症大鼠TLR4、NF-κB表达的影响
- Author:
Bin CHEN
;
Jie WANG
;
Jie PENG
;
Wu LI
;
Xuchu SU
;
Wenfang ZHU
;
Jiawei XU
;
Kewei SUN
- Publication Type:Journal Article
- Keywords:
Wen-Yang Jie-Du Hua-Yu granules;
anti-hepatic failure;
intestinal endotoxemia;
Toll-like receptor 4;
nuclear factor-кB
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2013;(5):818-824
- CountryChina
- Language:Chinese
-
Abstract:
phological changes in rat liver tissues. TLR4 and NF-κB expression in the liver tissues were measured by im-munohistochemistry . The results showed that compared with the normal group , the serum levels of transaminase ( ALT , AST ) and endotoxin of the model group were higher ( P < 0 . 01 ); and the degree of liver pathology injury was significantly increased; the TLR4 and NF-кB expression were increased (P < 0.01). Compared with the model group, the serum levels of transaminase (ALT, AST) and endotoxin of the experimental group were lower (P < 0.01), the degree of liver pathology injury was significantly lighter; the TLR4 and NF-кB expression were significantly lower (P < 0.01). It was concluded that the WYJDHY granules has a good role in the prevention and treatment of liver injury of rat model of hepatic failure IETM through the downregulation of liver expression of TLR4 and NF-кB in rat liver tissues , reducing serum levels of endotoxin , which may be one of the mecha-nisms on hepatic failure treatment .
