Clinical Research of Simotang Oral Liquid and Compound Glutamine Enteric Capsules for Treating Diarrhea-predominant Irritable Bowel Syndrome
10.3969/j.issn.1005-5304.2013.08.005
- VernacularTitle:四磨汤口服液联合复方谷氨酰胺肠溶胶囊治疗腹泻型肠易激综合征临床研究
- Author:
Yonghong WU
;
Guorong ZHENG
- Publication Type:Journal Article
- Keywords:
diarrhea-predominant irritable bowel syndrome;
liver depression and spleen deficiency syndrome;
Simotang oral liquid;
compound glutamine enteric capsules
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2013;(8):11-14
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of Simotang oral liquid combined with compound glutamine enteric capsules in the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D) belonging to liver depression and spleen deficiency pattern, and to explore its possible mechanism. Methods Sixty patients were randomly divided into two groups. The treatment goup (30 cases) took Simotang oral liquid and compound glutamine enteric capsules, the control group took Cerekinon and Medilac-S. The treatment course was 4 weeks. Clinical symptoms, 5-hydroxytryptamine (5-HT) and substance P (SP) of both groups were evaluated respectively before and after treatment. Recurrence rate and adverse reactions were recorded. Results The total effective rate after treating 1, 2, 4 weeks between the two groups had no significant difference (P>0.05). Four weeks later, in the treatment group, total score of the symptoms, abdominal distension and defecation urgency were apparently lower than that of control group (P<0.05). The levels of 5-HT and SP of the two groups significantly decreased after treatment (P<0.05). The recurrence rate at 4 weeks after drug withdrawal of treatment group and control group was 10.7%(3/28) and 32.1%(9/28) respectively. The difference between the two groups wasn’t significant (P>0.05). Obvious side effects were not found in the two groups. Conclusion Simotang oral liquid combined with compound glutamine enteric capsules has evident therapeutic effect on IBS-D of liver depression and spleen deficiency pattern, especially good at releasing abdominal distension and defecation urgency. The mechanism may be related with decreasing the levels of 5-HT and SP.
