Relative factors for osteonecrosis in the Chinese systemic lupus erythematosus patients:Meta-analysis
10.3969/j.issn.2095-4344.2013.35.015
- VernacularTitle:中国系统性红斑狼疮伴发骨坏死相关因素的Meta分析
- Author:
Zhengliang LUO
;
Xifu SHANG
;
Xu LI
;
Fei HU
;
Rui HE
- Publication Type:Journal Article
- Keywords:
bone and joint implants;
evidence-based medicine of bone and joint;
systemic lupus erythematosus;
osteonecrosis;
risk factor;
glucocorticoids;
vasc-ulitis;
hyperlipidemia;
Raynaud’s phenomenon;
case-control study;
Meta-analysis
- From:
Chinese Journal of Tissue Engineering Research
2013;(35):6314-6320
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Systemic lupus erythematosus is a kind of heterogeneous disease, and the difference of clinical features may also be the risk factors of osteonecrosis besides of treatment with glucocorticoids according to the literature. However, it remains controversial on the risk factors of osteonecrosis in systemic lupus erythematosus patients.
OBJECTIVE:To systematical y review the major risk factors of osteonecrosis in the Chinese patients with systemic lupus erythematosus.
METHODS:The CNKI database, CBMdisc database and Wanfang database were retrieved for the published case-control study literatures on the risk factors of osteonecrosis in the Chinese patients with systemic lupus erythematosus. The literatures met the inclusion and exclusion criteria were included, and a Meta-analysis was conducted by RevMan 5.0 and Stata software. Then, the pooled odd ratio and 95%confidence interval of each risk factor were calculated.
RESULTS AND CONCLUSION:Ten case-control study literatures were included involving 332 cases in the case group and 986 cases in the control group. The pooled odd ratio and 95%confidence interval of each risk factor of osteonecrosis in the Chinese patients with systemic lupus erythematosus were as fol ows:Raynaud’s
phenomenon 3.28(1.69-6.38), dental ulcer 2.95(2.13-4.09), renal involvement 1.21(0.83-1.74), vasculitis 5.64(2.84-11.21), hyperlipidemia 5.11(3.10-8.42), anti-phospholipid antibody 2.32(1.49-3.61) and joints involvement
2.02(1.33-3.07). It has been clear that the glucocorticoids is an independent risk factor of osteonecrosis in the patients with systemic lupus erythematosus. However, it is not the one and only risk factor. The fol owing risk factors of
vasculitis, hyperlipidemia, Raynaud’s phenomenon, dental ulcer, positive anti-phospholipid antibody and joints involvement are the risk factors of osteonecrosis in the patients with systemic lupus erythematosus.
