Fabrication and properties of low-crystallinity carbonate apatite monolith bone graft
10.3969/j.issn.2095-4344.2013.34.002
- VernacularTitle:低结晶性碳酸磷灰石团块骨移植材料的合成及性能☆
- Author:
Xin LIN
;
Min HOU
- Publication Type:Journal Article
- Keywords:
biomaterials;
tissue-engineered bone materials;
bone graft;
carbonate apatite;
calcium carbonate;
ammonium dihydrogen phosphate;
biomechanics;
low-crystal inity
- From:
Chinese Journal of Tissue Engineering Research
2013;(34):6067-6072
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:As a good candidate for bioresorbable bone graft, carbonate apatite monolith can be prepared by sintering procedure;however, sintering can cause carbonate loss and result in a much lower rate of
biodegradation compared to the human bone, thereby influencing the formation of new bone.
OBJECTIVE:To fabricate low-crystal inity carbonate apatite monolith as bone graft and test its properties. METHODS:Calcium carbonate monolith prepared by carbonation of Ca(OH) 2 monolith was treated in 1 mol/L
RESULTS AND CONCLUSION:The calcium carbonate completely transformed into low-crystal inity B-type
carbonate apatite after treated for 14 days. Diametral tensile strength of the final product was (10.27±1.08) MPa, which is adequate as a reconstruction material for bone defect. The carbonate content was (4.80±0.50)%, similar to that of the nature bone. The molar Ca/P was 1.63±0.01, indicating the Ca-deficient carbonate apatite is
obtained. The present method al ows an easy fabrication of low-crystal inity B-type carbonate apatite block with adequate strength and without sintering process.
ammonium dihydrogen phosphate solution at 60 ℃ up to 14 days. Diametral tensile strength was examined for biomechanical properties;X-ray diffraction analysis, Fourier transform infrared spectroscopy, scanning electron microscope observation and chemical analyses (carbonate, calcium and phosphate content) were also performed for physical and chemical properties.
