Observation on the effect of different types of statins combined with donepezil in the treatment of Alzheimer disease
10.3760/cma.j.issn.1008-6706.2013.18.001
- VernacularTitle:不同类型他汀类药物联合多奈哌齐治疗阿尔茨海默病的疗效观察
- Author:
Yichen YIN
;
Wuhua XU
;
Muzhen WANG
;
Suping ZHANG
- Publication Type:Journal Article
- Keywords:
Alzheimer disease;
Donepezil;
Atrovstation;
Simvastatin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(18):2721-2723
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of different types of statins combined with donepezil in the treatment of Alzheimer disease(AD).Methods According to the digital table,90 patients with AD were randomly divided into the statins A group(atrovstatin combined with donepezil) 31 cases,statins B group(simvastatin combined with donepezil)27 cases,and donepezil group(only with donepezil) 32 cases.All patients were treated for one year.The blood lipid level (including cholesterol (CH) and low density lipoprotein cholesterol (LDL-C),mini-mental state examination(MMSE),activity of daily living(ADL) and global deterioration scale (GDS) were detected and compared respectively among groups before and after treatment.Results The MMSE,ADL and GDS scores of the donepezil group were (17.00 ± 2.99) points,(60.44 ± 14.57) points,(4.28 ± 1.22) points,respectively,which were worse than those of the statins A group [(19.90 ± 3.07) points,(71.61 ± 18.50) points,(3.39 ± 1.15) points] (t =0.218,P ＜ 0.05,t =2.669,P ＜ 0.01,t =2.562,P ＜ 0.01) and statins B group [(19.88 ± 6.66) points,(71.89 ± 19.61) points,(3.37 ±l.39)points](t=l.959,P ＜0.05,t=2.991,P ＜0.0l,t=2,265,P ＜0.01).Conclusion The combination of donepezil and statins can effectively improve cognitive function and daily living ability in patients with AD,and its effect is superior to single use of donepezil.
