Clinical observation of cervical intra-epithelial neoplasia with high risk HPV infection after LEEP treatment

VernacularTitle:高频电波刀治疗宫颈上皮内瘤样变伴人乳头瘤病毒感染的临床观察
Author: Xuan SU ; Wei WU
Publication Type:Journal Article
Keywords: LEEP; CIN; Papillomavirus,human
From: Chinese Journal of Primary Medicine and Pharmacy 2013;20(16):2462-2464
CountryChina
Language:Chinese
Abstract: Objective To explore the curative effect of loop electrosurgical excision procedure (LEEP) on cervical intra-epithelial neoplasia(CIN) infected with high risk human papilloma virus (HR-HPV).Methods 80 CIN patients with HPV infection underwent LEEP were selected.HR-HPV DNA load was detected before operation and 3 months after operation,and at the same time,vaginal examination and cervical directed biopsy were conducted.Results Before LEEP operation,the differences between different levels of CIN HPV load were not significant(P ＞0.05,F =0.45).3 months after operation,CIN Ⅰ grade 19 cases (86.4％) turned to chronic inflammation,CIN Ⅱgrade 36 cases (83.7％) turned to chronic inflammation,CINⅢ grade 13 patients (86.6％) were chronic inflammation.Cervical HPV load postoperatively negative rate was 85％ and the lower HPV load,the higher postoperatively negative rate.Conclusion LEEP is the effective treatment for cervical lesion and can significantly decrease the HPV-DNA loading at cervix.