Effects and safety of intra-articular injection of recombinant human tumor necrosis factor-α receptor Ⅱ :IgG Fc fusion protein in patients with refractory knee effusion
10.3760/cma.j.issn.1008-6706.2013.15.030
- VernacularTitle:关节腔注射重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白治疗顽固性膝关节积液疗效和安全性观察
- Author:
Yukai WANG
- Publication Type:Journal Article
- Keywords:
oint effusion;
Inflammatory arthritis;
Recombinant human tumor necrosis factor-αreceptor Ⅱ;
IgG Fc fusion protein;
Intra-articular injection
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(15):2313-2314
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy and safety of the intra-articular injection of recombinant human tumor necrosis factor-α receptor Ⅱ:IgG Fc fusion protein (rhTNFR:Fc) in inflammatory arthritis patients with refractory knee effusion.Methods Ten inflammatory arthritis patients presented with refractory knee effusion after treatment of intra-articular steroid injection were involved.They received intra-articular injection rhTNFR:Fc (12.5mg twice weekly).The clinical efficacy and safety were assessed the first and second week after injection.Results At 1 week and 2 weeks,the total effective rate was 60％ and 70％ respectively.Patients and physicians global assessment score (visual analogue scale VAS 0-100mm),joint tenderness and movement pain scale (VAS) were significantly improved.Knee circumference was reduced as compared with baseline (all P ＜ 0.05).Conclusion Intra-artiular injection of rhTNFR:Fc in improving patients with refractory knee effusion is a worthwhile clinical treatment attempt.
