Effects of different doses of atorvastatin on serum Hcy and MMP-9 in patients with acute cerebral infarction

VernacularTitle:不同剂量阿托伐他汀对急性脑梗死患者血液同型半胱氨酸和基质金属蛋白酶-9的影响
Author: Weihua DIAO
Publication Type:Journal Article
Keywords: Cerebral infarction; Atorvastatin; Homocysteine; Matrix metalloproteinase-9
From: Chinese Journal of Primary Medicine and Pharmacy 2013;20(15):2281-2283
CountryChina
Language:Chinese
Abstract: Objective To study the effects of different doses of atorvastatin on serum homocysteine (Hcy) and matrix metallopmteinase-9 (MMP-9) in patients with acute cerebral infarction.Methods Ninety-patients with acute cerebral infarction were randomly divided into two groups,the observation group (n =45 cases) and the control group(n =45 cases).The patients in the observation group were treated by the conventional therapy plus atorvastatin 40mg/d,while the patients in the control group were treated by the conventional therapy plus atorvastatin 20mg/d.Hcy and MMP-9 were detected before and after treatment for one month.Results The total effective rate was 95.6％in the observation group and 86.7％ in the control group.There was significant difference between two groups(x2 =2.1951,P ＜ 0.05).Hcy and MMP-9 were decreased after treatment in both groups and those in the observation group were lower than in the control group (all P ＜ 0.05).Conclusion High-dose atorvastatin can improve patients with acute cerebral infarction through decreasing Hcy and MMP-9.