Clinical evaluation on efficacy and safety of nateglinide in the treatment of type 2 diabetes

VernacularTitle:那格列奈治疗2型糖尿病疗效及安全性研究
Author: Lin LI ; Debin XU
Publication Type:Journal Article
Keywords: Nateglinide; Repaglinide; Diabetes,type 2; Blood glucose
From: Chinese Journal of Primary Medicine and Pharmacy 2013;20(15):2271-2273
CountryChina
Language:Chinese
Abstract: Objective To evaluate the efficacy and safety of nateglinide,a new antidiabetic agent,in the treatment of type 2 diabetes.Methods 276 patients with type 2 diabetes mellitus,in accordance with the table of random number method,were divided into the nateglinide group 138 cases,repaglinide group 138 cases.The nateglinide group was given 30 mg nateglinide,and repaglinide group was given 0.5 mg repaglinide,3 times a day,oral administration 15min before meal.12 weeks for one period of treatment.FBG,2h PBG,HbAlc and security index were detected before and after treatment.Results After treatment,FBG,2h PBG and HbAlc indexes in the two groups were lower than before treatment,the differences were statistically significant(all P ＜ 0.05).The differences were not significant compared between the two groups (all P ＞ 0.05).No serious adverse events occurred in two groups.Conclusion Nateglinide can effectively control fasting and postprandial blood sugar in patients with type 2 diabetes.It is safe and reliable and worthy clinical promotion.