Pharmacokinetic study of potential drug shionone
10.3760/cma.j.issn.1008-6706.2013.15.012
- VernacularTitle:候选新药紫菀酮的药代动力学研究
- Author:
Zhiwei XIE
;
Rong ZHANG
;
Zhenhua ZHANG
;
Lan CHEN
- Publication Type:Journal Article
- Keywords:
Shionone;
Reversed phase high performance liquid chromatography;
Pharmacokinetics
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(15):2268-2270
- CountryChina
- Language:Chinese
-
Abstract:
Objective To develop a simple,sensitive,and accurate method for the determination of shionone in rat plasma after administration of shionone.Methods The separation was developed by HPLC on a Waters shieldTM RP18 column (150mm × 3.9mm,5 μm) with a mobile phase composed of acetonitrile-0.05％ phosphoric acid water (98:2) at a flow rate of 1.0 mL/min.UV Detector was set at 200nm.Results The linear range of the standard curves was 0.043-1.720 μg/ml with the correlation coefficient of 0.995.The intra-and inter-day precisions were all below 10％.Conclusion The developed method can be successfully applied to the pharmacokinetic study.
