Study on correlation between depth of sedation and Narcotrend index in Midazolam target-controlled infusion
10.3760/cma.j.issn.1008-6706.2013.15.006
- VernacularTitle:咪达唑仑靶控输注时镇静深度与Narcotrend指数的相关性研究
- Author:
Ruiyu LI
;
Yunna QU
;
Lixun WANG
;
Hui LI
;
Qitao HE
- Publication Type:Journal Article
- Keywords:
Midazolam;
Target controlled infusion;
Depth of sedation;
Narcotrend monitor
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(15):2252-2254
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the reliability of Narcotrend for monitoring the depth of sedation [the observer's assessment of alterness/sedation(OAA/S) scale] with midazolam and correlation between the depth of sedation and Narcotrend index.Methods 0 ASA Ⅰ-Ⅱ status patients scheduled for elective lower limb operations underwent spinal anesthesia,who were given target-controlled infusion of midazolam.Target plasma concentration was 50ng/ ml at first and increased by 10 ng/ml each grade until OAA/S scale became 1 point.Each target concentration infusion was maintained for 5min.Observe the patient the OAA/S scale to be 5 points.If the operation was not over yet,regulated the appropriate depth of sedation until the end of operation.The Narcotrend index of different OAA/S scale and heart rate,mean arterial pressure,respiration were recorded.Results In the deepening or recovery phase of sedation,OAA/S scales were correlated with Narcotrend index (Spearman' s r =0.786,0.652,all P ＜ 0.05).Conclusion Narcotrend is a good index to guide target controlled infusion of midazolam,the index is closely related with the depth of sedation of midazolam.
