Retrospective analysis of the influence of clopidogrel combined with proton pump inhibitor on the prognosis of the patients undergoing percutaneous coronary intervention
10.3760/cma.j.issn.1008-6706.2013.15.002
- VernacularTitle:氯吡格雷联合质子泵抑制剂对急性冠脉综合征患者行经皮冠脉介入术预后的影响
- Author:
Meihong CHEN
- Publication Type:Journal Article
- Keywords:
Clopidogrel;
Proton pump inhibitors;
Angioplasty,transluminal,percutaneous coronary
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(15):2243-2245
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the influence of clopidogrel combined with proton pump inhibitor(PPI) on the incidence rate of in-stent restenosis (ISR) in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention(PCI).Methods The clinical data of 132 ACS patients who were taking clopidogrel antiplatelet therapy were retrospectively analyzed.The control group (single clopidogrel) and observation group (clopidogrel +PPI) had 66 cases in each group.The incidence rate of ISR was compared between the two groups.Results The factor of gender,age,history of smoking,high blood pressure,heart function insufficiency,diabetes,peripheral vascular disease,oral medications,and the number of implanted stents in the two groups of patients with ACS may affect ISR factors constitute had no statistical significance (all P ＞ 0.05) ; ISR incidence rate of the observation group and the control group was 19.7％ and 9.1％,the difference was statistically significant (x2 =4.880,P ＜ 0.05).Conclusion PPI combined with clopidogrel could significantly increase ISR incidence rate of patients after PCI during follow up period of (12.0 ± 4.2)months,which should be carefully used in patients after PCI.
