The effect of low-dose dexamethasone in the treatment of neonatal meconium aspiration pneumonia and its influence on inflammatory cytokines
10.3760/cma.j.issn.1008-6706.2013.15.040
- VernacularTitle:小剂量地塞米松治疗新生儿胎粪吸入性肺炎的疗效及对炎性细胞因子的影响
- Author:
Xuemei LI
- Publication Type:Journal Article
- Keywords:
Meconium aspiration pneumonia;
Infant,newborn;
Dexamethasone;
Inflammatory Cytokines
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(15):2335-2337
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of low-dose dexamethasone in the treatment of neonatal meconium aspiration pneumonia and its influence on inflammatory cytokines.Methods 60 cases with neonatal meconium aspiration pneumonia were randomly divided into observation group and control group,30 cases in each group.The control group was given conventional treatment,the observation group was given low-dose dexamethasone treatment on the basis of the control group.Both groups had been treated for 3d,first ld 0.5mg/kg,2d 0.25mg/kg,3d 0.1 mg/kg.After 7 days,blood gas indicators and serum IL-6,IL-8,TNF2awere detected,the clinical efficacy was evaluated,the time of oxygen requirement and length of stay were recorded.Results The total effective rate of observation group and control group was 96.67％ (29/30) and 76.67％ (23/30) (x2 =6.497,P ＜ 0.05).The indicators of the observation group were significantly better than the control group,the average oxygen total time of the observation group and the control group was (6.1 ± 1.7) d and (10.2 ± 2.4) d (t =5.673,P ＜ 0.01).IL-6,IL-8,TNF2a of observation group and control group after treatment were (1.21 ±0.16) μg/L vs(3.07 ±0.24) μg/L,(1.13 ±0.14) μg/L vs (2.42 ± 0.33) μg/L,(2.61 ± 0.24) vs (4.07 ± 0.41) (all P ＜ 0.01).Conclusion The low-dose dexamethasone can reduce inflammatory cytokines levels and lung inflammation reaction,improve gas exchange,shorten the the aerobic time and the length of hospital stay,improve the short-term effect.
