The effect of hemostatic drug on coagulation status after operation of bladder tumor
10.3760/cma.j.issn.1673-4904.2013.23.011
- VernacularTitle:止血药对膀胱肿瘤患者术后凝血状态的影响
- Author:
Pengfei WANG
- Publication Type:Journal Article
- Keywords:
Hemostatic drug;
Bladder tumor;
Coagulation status
- From:
Chinese Journal of Postgraduates of Medicine
2013;36(23):30-32
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of hemostatic drug on coagulation status after operation of bladder tumor.Methods Eighty-two bladder tumor patients in hospital for treatment were selected,and were randomly divided into observation group and control group with 41 patients in each.The patients in observation group were treated with hemostatic drug after operation,and the patients in control group were treated without hemostatic drug.The coagulation status between two groups were compared after operation.Results The index of preoperative coagulation status between two groups had no significant difference (P＞ 0.05).Compared with the preoperative,the activated partial thromboplastin time(APTT) and prothrombin time (PT) in two groups were prolonged on postoperative 1,2 d,plasminogen activator inhibitor (PAI)-1,tissue plasminogen activator (t-PA),D-Dimer (D-D) were increased,platelet (PLT) was decreased,thrombin time(TT) was shortened,there were significant differences (P ＜ 0.05).On postoperative 1,2 d,Tr in observation group was shorter than that in control group[(14.36 ± 0.17) s vs.(15.42 ± 0.18) s,(14.36 ± 0.28) s vs.(15.29 ± 0.27) s],PAI-1,t-PA,D-D were significantly higher than those in control group [(98.19±2.32) μg/Lvs.(82.19±2.38) μg/L,(84.52±2.25) μg/Lvs.(72.94±2.26) μg/L,(27.06 ± 1.69) μg/L vs.(21.63 ± 1.16) μg/L,(27.28 ± 1.37) μg/L vs.(21.69 ± 1.19) μg/L,(7.06 ±0.08) μg/L vs.(1.89 ± 0.28) μg/L,(12.83 ± 1.05) μg/L vs.(1.96 ± 0.18) μg/L],there were significant differences (P＜0.05).No significant difference was found in PLT,APTT,PT between two groups (P＞0.05).The incidence of deep vein thrombosis (DVT) in observation group and control group was 7.32％(3/41),2.44％ (1/41),which had no significant difference (P ＞ 0.05).Conclusions The application of hemostatic drug can aggravate hypercoagulability of patients with bladder tumor after operation.Therefore,it should be carefully applied preventive hemostatic drug.
