Predictive value of cytokeratin polypeptide 19 level on prognosis of patients with first occurrence of papillary thyroid carcinoma
10.3760/cma.j.issn.1673-4904.2013.23.003
- VernacularTitle:细胞角蛋白多肽-19水平对新发甲状腺乳头状癌患者预后的影响
- Author:
Kun HU
;
Yanchu TONG
;
Chunyan LI
- Publication Type:Journal Article
- Keywords:
Cytokeratin polypeptide 19;
Papillary thyroid carcinoma
- From:
Chinese Journal of Postgraduates of Medicine
2013;36(23):7-10
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the relationship between plasma cytokeratin polypeptide 19 (CK 19) level and prognosis of patients with first occurrence of papillary thyroid carcinoma (PTC).Methods This prospective trial enrolled 60 patients with PTC.The plasma CK19 level was determined by ELISA and the other clinical data were collected on admission.All patients were followed up for 12 months.The patients were divided into recurrence group (27 patients) and non-recurrence group (33 patients) according to the results of follow-up.Results Single factor analysis showed that age,female,history of smoking,Graves disease,occupational exposure,the level of thyroid peroxidase antibody,thyroglobulin antibody,triglyceride and CK19 between two groups had significant difference (P ＜ 0.05).Multiple factors analysis showed that female,history of smoking,occupational exposure,the level of thyroid peroxidase antibody,thyroglobulin antibody and CK19 were independent risk factors for recurrence (P =0.01).The recurrence rate of CK19 ≥4.12 μg/L patients was 79.31％ (23/29),significantly higher than that in CK19 ＜4.12 μg/L patients [12.90％ (4/31)] (x2 =5.17,P ＜ 0.05).The recurrence rate of CK19 ≥ 4.12 μ g/L was significantly higher than that in CK19 ＜4.12 μ g/L (x2 =4.11,P ＜ 0.05).Conclusions The plasma CK19 level is an independent risk factor for recurrence of PTC patients.It can be used as a significant independent predictor for recurrence of PTC patients.
