A clinical study of DCF scheme and ECF scheme in the treatment of advanced gastric cancer
10.3760/cma.j.issn.1673-4904.2013.17.006
- VernacularTitle:DCF方案与ECF方案治疗进展期胃癌的临床研究
- Author:
Jun LIU
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Cisplatin;
Epirubicin;
Docetaxel;
5-fluorouracil
- From:
Chinese Journal of Postgraduates of Medicine
2013;36(17):17-19
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect and adverse reactions of DCF scheme (docetaxel + cisplatin + 5-fluorouracil) and ECF scheme (epirubicin + cisplatin + 5-fluorouracil) in the treatment of advanced gastric cancer.Methods Sixty-two patients with advanced gastric cancer were randomly divided into two groups with 31 cases each,DCF group was given DCF scheme therapy,ECF group was given ECF scheme therapy.After completing at least 2 cycles of chemotherapy the curative effect was evaluated.Results DCF group complete response in 2 patients,partial response in 10 patients,stable condition in 11 patients,disease progression in 8 cases,the effective rate was 38.71％ (12/31),ECF group complete response in 1 patient,partial response in 9 patients,stable condition in 10 patients,disease progression in 11 patients,the effective rate was 32.26％ (10/31),there was no significant difference in the effective rate between the two groups (x2 =0.28,P ＞ 0.05).The median progression-free time in DCF group was 5.9 months,ECF group was 5.7 months.Two groups during the period of chemotherapy adverse reactions mainly in bone marrow suppression,gastrointestinal reactions and peripheral neuritis,were given priority to with 1,2 degrees.There were no significant difference in hemoglobin decline rate,white blood cells,platelets drop incidence rate of descent,stomatitis incidence,nausea and vomiting,diarrhea incidence rate between two groups (P ＞ 0.05).Peripheral neuritis in DCF group was obviously higher than that in ECF group [77.42％ (24/31) vs.9.68％ (3/31),P ＜ 0.05].Conclusion DCF scheme and ECF scheme in the treatment of advanced gastric cancer are relatively satisfied curative effect,adverse reaction is given priority to with 1,2 degrees,DCF scheme of peripheral nerve inflammation in patients with a high incidence,but all can tolerate.
