Clinical significance of perineural invasion on the patients with gastric cancer

VernacularTitle:神经浸润在胃癌中的临床意义
Author: Qingbing WANG ; Yanjun WANG
Publication Type:Journal Article
Keywords: Stomach neoplasms; Prognosis; Perineural invasion
From: Chinese Journal of Postgraduates of Medicine 2013;36(21):35-37
CountryChina
Language:Chinese
Abstract: Objective To investigate the effect of perineural invasion (PNI) on evaluating the prognosis of patients with gastric cancer.Methods The clinical data of 116 patients who underwent gastric resection were analyzed retrospectively,all of the paraffin sections were stained with S-100 albumen,the association between PNI with clinicopathological features and prognosis were analyzed.Results PNI was positive in 41 of all the 116 patients (35.3％,41/116).The occurrence of PNI related with depth of invasion,histological type,lymph node metastasis (P ＜0.05),unrelated with gender,tumor size,Borrmann classification,TNM stage (P ＞0.05).One hundred and five patients completed follow-up,the median follow-up time was 49 months,the median life span and 5-year survival of the PNI-positive patients were significantly worse than that of PNI-negative patients [23.6 months vs.43.8 months,30.6％(ll/36) vs.53.6％ (37/69),P ＜ 0.05].Univariate and multivariate analysis were prompted PNI with perineural invasion (P ＜ 0.05).Conclusions The PNI-positive tumor cell may have more power in invasiveness,and it could serve as an independent predictor of prognosis of gastric cancer.