Tissue-engineered nerve for repair of peripheral nerve injuries
10.3969/j.issn.2095-4344.2013.41.023
- VernacularTitle:组织工程化神经修复周围神经创伤的应用
- Author:
Chongyang FU
;
Jia ZHAO
;
Wei QU
- Publication Type:Journal Article
- Keywords:
peripheral nerves;
nerve injuries;
stem cells;
Schwann cells;
biocompatible materials
- From:
Chinese Journal of Tissue Engineering Research
2013;(41):7335-7340
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Recent development of bioengineering technology and tissue-engineered nerve brings a new hope for the treatment of peripheral nerve injuries, which has gradual y become a research spot. OBJECTIVE:To review the new progress in the repair of peripheral nerve injuries using seed cells, biomaterials and tissue-engineered nerve construction technology. METHODS:PubMed and CNKI were searched by the first authors for articles concerning nerve tissue engineering and repair of peripheral nerve injuries published prior to July 2013. The keywords were“tissue engineering, peripheral nerves, nerve injuries, stem cells, Schwann cells, scaffold, growth factor”in English and Chinese, respectively. The articles published recently or in the authorized journals were preferred in the same field. Final y, 63 articles were included in result analysis. RESULTS AND CONCLUSION:Up to now, there is a great advance in the tissue engineering technology for the repair of peripheral nerve injuries. However, most studies are stil in experimental step. For the clinical application of nerve tissue engineering, some problems to be solved include:(1) source and ethics of seed cells;(2) immunological rejection fol owing cellproliferation and transplantation;(3) stability and oncogenicity of transplanted cells;(4) degradation rate, optimal porosity, tube thickness and shape;(5) repair timing for in vitro tissue-engineered nerve construction;(6) local release and regulation of various neurobiological factors. With the development of science, many patients with nerve injuries can profit from the solve of these problems.
