Clinical analysis of pemetrexed chemotherapy combined with radiotherapy in brain metastases of lung adenocarcinoma
10.3760/cma.j.issn.1672-7088.2013.19.002
- VernacularTitle:培美曲塞化疗联合放疗治疗肺腺癌脑转移的临床观察
- Author:
Cheng ZHANG
- Publication Type:Journal Article
- Keywords:
Brain metastases of lung adenocarcinoma;
Pemetrexed;
Radiotherapy;
Free survival
- From:
Chinese Journal of Practical Nursing
2013;29(19):4-7
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effects of pemetrexed chemotherapy combined with radiotherapy in brain metastases of lung adenocarcinoma patients.Methods The data of lung adenocarcinoma patients with brain metastases were conducted retrospectively diagnostic analysis,and they were stratified randomized divided into the observation group (26 cases) and the control group (25 cases).The observation group was treated with pemetrexed chemotherapy combined with radiotherapy; the control group was treated with radiotherapy alone.Brain metastases,quality of life,short-term efficacy,adverse reactions,and patients' survival period were observed.Results The efficacy and quality of life of patients in the observation group were improved significantly than those of the control group,and adverse reactions were mild,the survival period was not significant between two groups.Conclusions Pemetrexed in combination with radiation therapy for the treatment of brain metastases from lung adenocarcinoma can effectively improve the short-term efficacy and quality of life of patients,and the adverse reactions are mild,it possess great application value in the treatment of brain metastases of lung adenocarcinoma.
