Effect of angiotensin-converting enzyme inhibitor on acute kidney injury in patients with sepsis

VernacularTitle:血管紧张素转化酶抑制剂对脓毒症患者急性肾损伤的影响
Author: Ping SHU ; Huanhong XIONG ; Yan HE ; Huiyun ZHOU
Publication Type:Journal Article
Keywords: Sepsis; Acute kidney injury; Angiotensin-converting enzyme inhibitor; APACHE Ⅱscore
From: Chinese Journal of Emergency Medicine 2013;22(7):779-782
CountryChina
Language:Chinese
Abstract: Objective To investigate the protective effect of angiotensin-converting enzyme inhibitor (ACEI) on kidney function in patients with sepsis.Methods Eighty-seven patients with sepsis were randomly (random number) divided into the routine treatment (A group,n ＝45) and the ACEI intervention group (B group,n =42).Patients were managed by international guidelines for sepsis in A group and were treated with benazepril (ACEI) 20 mg a day in addition in B group.Serum creatinine and cystatin C were detected and APACHE Ⅱ scores and urine output were recorded on the 1st,3rd and 7th day.Those laboratory findings and APACH Ⅱ score were compared between two groups.The incidence of acute kidney injury (AKI) and abnormal cystatin C levels were compared between two groups.Results In B group,serum creatinine and cystatin C of patients were lower compared with A group.The incidence of AKI and abnormal cystatin C and APACHE Ⅱ scores were reduced in B group compared with the A group.Conclusions Benazepril improved sepsis-induced AKI and patient conditions.