The study of heart-type fatty acid binding protein in the PCI therapy for patients with acute myocardial infarction
10.3760/cma.j.issn.1671-0282.2013.06.014
- VernacularTitle:心型脂肪酸结合蛋白在心梗患者行介入治疗中的意义
- Author:
Jian ZHANG
;
Chunsheng LI
- Publication Type:Journal Article
- Keywords:
ST segment elevation myocardial infarction (STEMI);
Percutaneous coronary intervention (PCI);
Heart-type fatty acid binding protein (H-FABP);
cTnI;
ST segment drop amplitude;
Coronary lesions;
Myocardial injury;
Myocardial reperfusion
- From:
Chinese Journal of Emergency Medicine
2013;22(6):612-615
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the change and clinical significance of the heart type fatty acid binding protein (H-FABP) in ST Segment Elevation Myocardial Infarction (STEMI) after percutaneous coronary intervention (PCI).Methods Of 178 STEMI patients were recruited and were separated as ST segment drop group (137) and ST segment non-drop group (41).All the patients received H-FABP and cTnI tests,and re-tested H-FABP on 1 h,6 h,12 h and 24 h after the PCI,and re-tested cTnI on 12 h and 24 h after the PCI.Also,the ST segment drop amplitude (ΣSTR) was measured 2 h after the PCI.Results The demographics of both groups were similar.In both groups,the H-FABP on 6 h after PCI was significantly higher than the value measured prior to PCI.In the ST segment drop group,the H-FABP was reduced to normal value on 24 h after PCI,while it was not in the ST segment non-drop group.Conclusions The H-FABP elevation is associated with the severity of coronary lesions in ST segment elevation myocardial infarction,and the PCI may be involved in the H-FABP changes.ΣSTR≥50％ and normal HFABP may be used as index for judgment of myocardial injury and myocardial reperfusion.
