Clinical observation on the treatment of idiopathic hyperprolactinemia infertility by self-designed Bushen Shugan decoction combined with bromocriptine
10.3760/cma.j.issn.1673-4246.2013.08.010
- VernacularTitle:自拟补肾疏肝汤联合溴隐亭用于特发性高催乳素血症性不孕患者的临床研究
- Author:
Liyun HUANG
- Publication Type:Journal Article
- Keywords:
Chinese medicine;
Bromocriptine;
Hyperprolactinemia;
Infertility
- From:
International Journal of Traditional Chinese Medicine
2013;35(8):701-703
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy of the treatment of idiopathic hyperprolactinemia infertility by Chinese medicine combined with bromocriptine.Methods 80 patients diagnosed of idiopathic hyperprolactinemia infertility were randomly recruited into a control group and a experimental group.The control group was treated with bromocriptine alone and the experimental group was treated additionally with self-designed Bushen Shugan decoction on the basis of the control group.The improvement of the clinical symptoms and follicular development were compared between the two groups.The data of ovulation and pregnancy rate was collected.The serum prolactin level and pregnancy outcomes afterdrug withdrawal was followed up and the recurrences was evaluated.Results The follicular development of the experimental group was improved greatly.Its ovulation rate was 72.5％(29/40),pregnancy rate was 60.0％ (24/40) and recurrence rate was 10.0％ (4/40).The follicular development of the control group was not obvious.Its ovulation rate was 27.5％(11/40),pregnancy rate was 20.0％(8/40)and recurrence rate was 35.0％ (14/40).The difference between the two groups was statistically significant (x2＝ 16.200,13.333,7.168,P＜0.05).Besides,there was no miscarriage,premature delivery and fetal malformations in the experimental group.Conclusion The treatment of idiopathic hyperprolactinemia infertility by Chinese medicine combined with bromocriptine had the characteristics of sound clinical efficacy,little side effect,high ovulation and pregnancy rate,low recurrence and good pregnancy outcomes.
