Changes in serum concentrations of angiogenic factors in patients with unstable angina pectoris
10.3760/cma.j.issn.1671-0282.2013.07.004
- VernacularTitle:不稳定型心绞痛患者血清血管生成因子质量浓度的变化
- Author:
Chun GUI
;
Fang DU
;
Qinling NONG
;
Binjing LIAN
;
Liguang ZHU
- Publication Type:Journal Article
- Keywords:
Unstable angina pectoris;
Diabetes;
Angiogenic factors;
Vascular endothelial growth factor;
Angiopoietin
- From:
Chinese Journal of Emergency Medicine
2013;22(7):712-715
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the changes in serum concentrations of angiogenic factors in patients with unstable angina pectoris.Methods A total of 57 patients with unstable angina pectoris were eligible for study and divided into diabetes group (n =23) and non-diabetes group (n =34).Exclusion criteria included complicated diseases,symptomatic peripheral vascular diseases,renal or liver diseases,cerebral embolism and evidence of ongoing infection.Another 36 age-matched healthy subjects from medical examination center were enrolled as control group.Serum samples were collected,and serum concentrations of vascular endothelial growth factor (VEGF),angiopoietin-1,angiopoietin-2,angiogenin,angiostatin,basic fibroblast growth factor (bFGF) and platelet-derived growth factor-BB (PDGF-BB) were measured by using cytokine array technology.The data were analyzed by independent-samples t test with the SPSS 13.0statistic software package.Results Compared with the control group,the serum concentrations of VEGF and angiopoietin-2 were significantly increased in patients with unstable angina pectoris (both P ＜ 0.01).Whereas,no significant differences in serum concentrations of angiogenin,angiopoietin-1,angiostatin,bFGF,and PDGF-BB were detected between control group and patient groups.There were no significant differences in serum concentrations of above all 7 biomarkers between diabetes group and non-diabetes group.Conclusions Serum concentrations of VEGF and angiopoietin-2 were increased in patients with unstable angina pectoris,and diabetes didn' t affect the increases in serum concentrations of VEGF and angiopoietin2 caused by unstable angina pectoris.
