Silent information regulator 1 and cerebral ischemia
10.3760/cma.j.issn.1673-4165.2013.07.010
- VernacularTitle:沉默信息调节因子1与脑缺血
- Author:
Xuan ZHANG
;
Fuqiang GUO
;
Ben WEI
- Publication Type:Journal Article
- Keywords:
Sirtuin 1;
Brain Ischemia;
Cerebrovascular Circulation;
Inflammation;
Oxidative Stress
- From:
International Journal of Cerebrovascular Diseases
2013;21(7):554-558
- CountryChina
- Language:Chinese
-
Abstract:
Silent information regulator 1 (SIRT1) is a NAD+-dependent histone deacetylase,which plays an important role in cerebral ischemia.It mainly stabilizes cerebral vascular endothelium,prevents vascular stenosis and the anti-inflammatory and anti-oxidative stress effects after cerebral ischemia.This article reviews the protective effects of STRT1 and its related mechanisms in cerebral ischemia.
