The-1562 C/T polymorphism of matrix metalloproteinase-9 gene and the risk of ischemic stroke: a meta-analysis
10.3760/cma.j.issn.1673-4165.2013.07.003
- VernacularTitle:基质金属蛋白酶9基因-1562 C/T多态性与缺血性卒中风险:汇总分析
- Author:
Mingjie ZHANG
;
Jingcheng LI
;
Yun LIU
;
Yanwei YIN
;
Lili ZHANG
- Publication Type:Journal Article
- Keywords:
Ischemic stroke;
Matrix metalloproteinase 9;
Polymorphism;
Meta-analysis
- From:
International Journal of Cerebrovascular Diseases
2013;21(7):522-526
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the-1562 C/T polymorphism of matrix metalloproteinase-9 (MMP-9) and the risk of ischemic stroke.Methods All the relevant literatures published were searched from PubMed,Embase,MEDLINE,Web of Science as well as CBMdisc and CNKI before May 2013.After extracting data,a meta-analysis of the studies meeting the requirements was conducted by using Review Manager Version 5.0 and Stata 11.0 software.The effect size was pooled and odds ratio (OR) and 95％ confidence interval (CI) were calculated.Results Six studies were enrolled,including 1115 patients and 979 controls.The ORs after pooled analysis (95％ CIs) were C/T vs.C/C:1.10 (0.71-1.71) and T/T vs.C/C:1.78 (0.89-3.57) of the codominant genetic model,respectively; C/T + T/T vs.C/C:1.13 (0.76-1.67) of the dominant genetic model; T/T vs.C/T + C/C:1.79 (0.90-3.57) of the recessive genetic model,which suggested that there was no significant correlation between the-1562 C/T polymorphism of MMP-9 gene and the risk of ischemic stroke.The analysis of 5 studies in Chinese populations showed that the ORs (95％ CIs) of the above 4 genetic models were 1.24 (0.76-2.04),1.43 (0.52-3.92),1.25 (0.80-1.97),and 1.33 (0.49-3.62),respectively.There were also no significant differences.Conclusions According to the analysis of the available literatures,there was no significant correlation between the-1562 C/T polymorphism of MMP-9 gene and the risk of ischemic stroke.
