ATP-binding cassette transporter A1 R219K polymorphism and the risk of ischemic stroke in Chinese populations: a meta-analysis
10.3760/cma.j.issn.1673-4165.2013.07.002
- VernacularTitle:ATP结合盒转运体A1基因R219K多态性与中国人缺血性卒中风险:汇总分析
- Author:
Rongyao HOU
;
Xiaoyan ZHU
;
Xudong PAN
;
Ruiyou GUO
;
Teng MA
;
Xiang XU
- Publication Type:Journal Article
- Keywords:
ATP-Binding Cassette Transporters;
Polymorphism,Genetic;
Stroke;
Brain Ischemia;
Meta-Analysis;
China
- From:
International Journal of Cerebrovascular Diseases
2013;21(7):517-521
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between ATP-binding cassette transporter A1 (ABCA1) R219K polymorphism and ischemic stroke in Chinese populations.Methods The case control studies of the correlation between Chinese ABCA1 R219K polymorphism and ischemic stroke published before May 2013 were collected using comprehensive literature search.The Stata 11.0 software was used to conduct metaanalysis.Odds ratio (OR) and its 95％ confidence interval (CI) was used to evaluate the strength of association between the gene polymorphism and ischemic stroke.Results A total of 10 studies met the criteria and were included in the analysis,including 1 619 patients in the patient group and 1907 in the control group.The selected literature had no obvious bias.Meta-analysis showed that the risk of ischemic stroke in patients carrying RK + KK genotype significantly decreased 8％ (OR 0.92,95％ CI 0.88-0.96; P =0.000)compared to those carrying RR genotype.The risk of ischemic stroke in patients carrying KK genotype significantly decreased 36％ compared to those carrying RR genotype (OR 0.64,95％ CI 0.44-0.94; P =0.02).The risk of ischemic stroke in patients carrying RK genotype significantly decreased 19％ compared to those carrying RR genotype (OR 0.81,95％ CI 0.69-0.95; P =0.009).The risk of ischemic stroke in patients carrying K allele significantly decreased 17％ compared to those carrying R allele (0R 0.83,95％ CI 0.69-0.99; P =0.036).Conclusions ABCA1 R219K polymorphism is associated with the susceptibility of ischemic stroke in Chinese.K allele may be a genetic protective factor for ischemic stroke in Chinese populations.
