microRNAs: therapeutic targets for ischemic stroke
10.3760/cma.j.issn.1673-4165.2013.05.010
- VernacularTitle:微小RNA:缺血性卒中的治疗靶点
- Author:
Junjiang LU
;
Jiangquan HAN
- Publication Type:Journal Article
- Keywords:
MicroRNAs;
Stroke;
Brain Ischemia;
Genetic Therapy
- From:
International Journal of Cerebrovascular Diseases
2013;21(5):385-388
- CountryChina
- Language:Chinese
-
Abstract:
microRNAs (miRNAs) are a class of small non-coding RNAs (length 21 to 25 nt).They can complement and bind to 3' non-coding region of their target genes,directly degrade target genes or inhibit the translation of encoding proteins,and extensively participate in development,metabolism,apoptosis,and a variety of disease processes.Studies have shown that miRNAs play important roles in the occurrence and development of ischemic stroke,and participate in post-stroke protection and regulation of repair mechanisms.
