Clinical efficacy of magnesium isoglycyrrhizinate injection in protecting liver function for patients on chemotherapy with 5-fluorouracil

VernacularTitle:5-氟尿嘧啶化疗患者应用异甘草酸镁保护肝功能临床观察
Author: Chunshan HAN ; Lu GAO ; Lingmin HAN
Publication Type:Journal Article
Keywords: Glycyrrhizic acid; Antineoplastic combined chemotherapy protocols
From: Chinese Journal of General Practitioners 2013;12(4):288-289
CountryChina
Language:Chinese
Abstract: A total of 116 hospitalized patients between May 2006 and March 2012 were divided into observation(n =39),treatment control (n =41) and blank control group (n =36).All groups received standard doses of chemotherapy with 5-fluorouracil.Patients in observation group received a daily intravenous infusion of 100 mg magnesium isoglycyrrhizinate plus chemotherapy while those in the treatment control group a daily 1.2 g reduced glutathione intravenous infusion plus chemotherapy.And the blank control group accepted chemotherapy alone.The parameters of liver function,including aspartate aminotransferase,alkaline phosphatase,gamma glutamyl transferase,lactate dehydrogenase,total bilirubin and albumin,were recorded and compared at Week 1.No significantly difference in the above parameters was found in observation group(P ＞ 0.05).However,in treatment control and blank control groups,significant statistical differences existed in some of the parameters (P ＜ 0.05).Magnesium Isoglycyrrhizinate is an efficient protector of liver function for patients on chemotherapy with 5-fluorouracil.