Clinical characteristics of 12 cases of chronic active Epstein-Barr virus infection

VernacularTitle:慢性活动性EB病毒感染12例临床分析
Author: Xiaochun SHI ; Hongwei FAN ; Wei Lü ; Xiaoqing LIU
Publication Type:Journal Article
Keywords: Herpesvirus 4,human; Infection
From: Chinese Journal of General Practitioners 2013;12(4):283-285
CountryChina
Language:Chinese
Abstract: The medical records of all 12 patients diagnosed as chronic active Epstein-Barr virus (CAEBV) infection at our hospital were analyzed retrospectively.There were 7 males and 5 females with a median onset age of 28 years.CAEBV was characterized by fever,splenomegaly,hepatomegaly and lymphadenopathy,etc.The abnormalities of laboratory examination included liver dysfunction,thrombocytopenia,anemia and leucopenia.EBV-DNA detected by real-time polymerase chain reaction was (1.7 × 103-3.5 × 107) copies/μg DNA in peripheral blood mononuclear cell.Among them,the outcomes were death (n =5),lost to follow-up (n =2) and T cell lymphoma (n =1).It is necessary to improve our awareness of CAEBV infection because of its poor prognosis and high mortality.