Measurement of cell-mediated immune function in elderly renal allograft recipients by ImmuknowTM assay

VernacularTitle:ImmuknowTM法检测细胞免疫功能在老年肾移植中的应用52例
Author: Jinquan CAI ; Jianming TAN ; Qinghua WANG ; Hao ZHOU ; Weizhen WU ; Shunliang YANG
Publication Type:Journal Article
Keywords: Kidney transplantation; Aged; Graft rejection; Infection; CD4-positive T-lymphocytes
From: Chinese Journal of Organ Transplantation 2013;34(8):463-465
CountryChina
Language:Chinese
Abstract: Objective To evaluate the values of cell-mediated immune function in elderly renal allograft recipients.Method The levels of immuknowTM ATP was sequentially monitored by means of Cylex immuknowTM assay in 52 elderly renal allograft recipients including 11 with infection and 8 with acute rejection.Results No statistically significant difference was found between stable allograt function and uremia (P＞0.05).The levels of immuknowTM ATP during infection was significantly lower than those with stable allograft function with acute rejection (P ＜ 0.01).The levels of immuknowTM ATP during acute rejection was significantly higher than those with stable allograft function with infection (P＜0.01).Conclusion Sequential monitoring of immuknowTM ATP is helpful for elderly renal allograft recipients in individualized immunosuppression therapy.Cylex immuknowTM assay can be used as a potent tool for assessment of high risk in infection and rejection.