Osteocyte — A new target for the treatment of osteoporosis

VernacularTitle:骨细胞——治疗骨质疏松的新靶点
Author: Xiyu WU ; Xianping WU ; Eryuan LIAO
Publication Type:Journal Article
Keywords: Osteocyte; Osteocyte death; Bone remodeling; Sclerostin; Osteoporosis
From: Chinese Journal of Endocrinology and Metabolism 2013;29(7):627-630
CountryChina
Language:Chinese
Abstract: The osteocyte has been found to be an orchestrator of bone remodeling.The damage of bone leads to osteocyte apoptosis.Sclerostin secreted by osteocyte causes feedback inhibition of bone formation,so inhibition of sclerostin expression has become a new target of treatment for osteoporosis.It seems resonable to direct clinical practise and treatment of metabolic bone diseases through understanding the function of osteocyte in the process of bone remodeling.