Recent advances in molecular targeted therapy and expression of iodine uptake relative protein in papillary thyroid carcinoma with BRAFV600E mutation
10.3760/cma.j.issn.1000-6699.2013.07.022
- VernacularTitle:BRAFV600E突变对甲状腺乳头状癌摄碘相关蛋白表达影响及相关分子靶向治疗
- Author:
Qiuli DU
;
Tao HUANG
- Publication Type:Journal Article
- Keywords:
BRAFV600E;
Papillary thyroid cancer;
Sodium iodide symporter;
Thyroid stimulating hormone receptor;
Molecular targeted therapy
- From:
Chinese Journal of Endocrinology and Metabolism
2013;29(7):624-626
- CountryChina
- Language:Chinese
-
Abstract:
Type-B RAF (BRAF) gene is one of the most popular genes of thyroid carcinoma in recent studies,and its mutation has significant relationships with the occurrence,development,treatment,and prognosis of papillary thyroid carcinoma(PTC).The influence of BRAFV600E mutation on the expression of iodine uptake relative proteins in PTC cells and the value of molecular targeted therapy with BRAFV600Einhibitors in the clinical treatment of PTC in the future were summarized in this review.
